1-Butanol → 6-[4-(2-Pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidin-4-amine

HRID 802280Notes

Reaction equation

HRID 802280 reaction equation
[CH2:31]([OH:32])[CH2:33][CH2:34][CH3:35].[CH:9]([N:10]([CH:11]([CH3:12])[CH3:13])[CH2:14][CH3:15])([CH3:16])[CH3:17].[Cl:1][c:2]1[cH:3][c:4]([NH2:8])[n:5][cH:6][n:7]1.[N:18]1([CH2:23][CH2:24][N:25]2[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]2)[CH2:19][CH2:20][CH2:21][CH2:22]1>>[c:2]1([N:28]2[CH2:27][CH2:26][N:25]([CH2:24][CH2:23][N:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)[CH2:30][CH2:29]2)[cH:3][c:4]([NH2:8])[n:5][cH:6][n:7]1

Participants

5

Reactant 4

HCID 2631-ButanolHCID 81531DiisopropylethylamineHCID 2380124-Amino-6-chloropyrimidineHCID 27372501-[2-(Pyrrolidin-1-yl)ethyl]piperazine

Product 1

HCID 219346496-[4-(2-Pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidin-4-amine

Sources & evidence

ORD record
ord-d5b307c94a204a139cbe0dff62b2a529
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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