Hydrochloric Acid → tert-Butyl 4-(3,3-difluoroazetidin-1-yl)piperidine-1-carboxylate

HRID 802374Notes

Reaction equation

HRID 802374 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[C:22]([O:23][BH-:24]([O:25][C:26](=[O:27])[CH3:28])[O:29][C:30](=[O:31])[CH3:32])(=[O:33])[CH3:34].[ClH:15].[F:16][C:17]1([F:21])[CH2:18][NH:19][CH2:20]1.[Na+:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([N:19]2[CH2:18][C:17]([F:16])([F:21])[CH2:20]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 2724942TriacetoxyborohydrideHCID 27582483,3-Difluoroazetidine

Product 1

HCID 59606191tert-Butyl 4-(3,3-difluoroazetidin-1-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-a5e237362131466c905a6d85c9e78081
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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