Water → tert-Butyl 4-[(5-bromopyrimidin-2-yl)oxy]piperidine-1-carboxylate

HRID 802470Notes

Reaction equation

HRID 802470 reaction equation
[C:15](=[O:16])([O-:17])[O-:18].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]1.[Cl:26][c:27]1[n:28][cH:29][c:30]([Br:33])[cH:31][n:32]1.[Cs+:19].[Cs+:20].[O:21]=[CH:22][N:23]([CH3:24])[CH3:25].[OH2:34]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:27]2[n:28][cH:29][c:30]([Br:33])[cH:31][n:32]2)[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 6066655-Bromo-2-chloropyrimidineHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 23115964tert-Butyl 4-[(5-bromopyrimidin-2-yl)oxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-e31a29b0de884c58bfd00fbebf1d60d3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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