Trifluoroacetic acid → 2-(5-Chloro-1H-indazol-7-yl)-2-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)acetonitrile
Reaction equation
[Cl:39][c:40]1[cH:41][c:42]2[cH:43][n:44][nH:45][c:46]2[c:47]([CH:49]([O:50][CH2:51][C:52]2([c:65]3[cH:66][cH:67][c:68]([F:71])[cH:69][cH:70]3)[CH2:53][CH2:54][N:55]([C:58]([O:59][C:60]([CH3:61])([CH3:62])[CH3:63])=[O:64])[CH2:56][CH2:57]2)[C:72]#[N:73])[cH:48]1.[Cl:8][c:9]1[cH:10][c:11]2[c:12]([c:13]([CH:14]([O:15][CH2:16][C:17]3([c:18]4[cH:19][cH:20][c:21]([F:22])[cH:23][cH:24]4)[CH2:25][CH2:26][N:27]([CH3:28])[CH2:29][CH2:30]3)[C:31]([O:32][CH3:33])=[O:34])[cH:35]1)[nH:36][n:37][cH:38]2.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[Cl:39][c:40]1[cH:41][c:42]2[cH:43][n:44][nH:45][c:46]2[c:47]([CH:49]([O:50][CH2:51][C:52]2([c:65]3[cH:66][cH:67][c:68]([F:71])[cH:69][cH:70]3)[CH2:53][CH2:54][N:55]([CH3:58])[CH2:56][CH2:57]2)[C:72]#[N:73])[cH:48]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-6308d35c8ca84daa9e9133ea14271863
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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