Water → N-(2-t-butoxycarbonylaminophenyl)-4-{5-[2-(methylthio)pyrimidin-4-yl]thien-2-yl}benzamide

HRID 802666Notes

Reaction equation

HRID 802666 reaction equation
[Br:33][c:34]1[cH:35][cH:36][c:37](-[c:39]2[n:40][c:41]([S:45][CH3:46])[n:42][cH:43][cH:44]2)[s:38]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[c:10]([NH:15][C:16]([c:17]2[cH:18][cH:19][c:20]([B:23]3[O:24][C:25]([CH3:26])([CH3:27])[C:28]([CH3:29])([CH3:30])[O:31]3)[cH:21][cH:22]2)=[O:32])[cH:11][cH:12][cH:13][cH:14]1.[C:48]([O:49][CH2:50][CH3:51])(=[O:52])[CH3:53].[OH2:47]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[c:10]([NH:15][C:16]([c:17]2[cH:18][cH:19][c:20](-[c:34]3[cH:35][cH:36][c:37](-[c:39]4[n:40][c:41]([S:45][CH3:46])[n:42][cH:43][cH:44]4)[s:38]3)[cH:21][cH:22]2)=[O:32])[cH:11][cH:12][cH:13][cH:14]1

Participants

5

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 28205344-(5-Bromothiophen-2-yl)-2-methylsulfanylpyrimidineHCID 59830883N-(2-t-Butoxycarbonylaminophenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Product 1

HCID 68408076N-(2-t-butoxycarbonylaminophenyl)-4-{5-[2-(methylthio)pyrimidin-4-yl]thien-2-yl}benzamide

Sources & evidence

ORD record
ord-880cd22512fc4320952fc86842be01e2
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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