反应详情

温度

120 °C

1-(4-Cyclopropanecarbonyl-3-fluoro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-198b: 175 mg, 0.516 mmol) in hydrazine hydrate solution (10 mL) was taken in a reaction flask. The flask was refluxed at 120° C. overnight. The reaction was monitored by TLC (5% MeOH in CHCl3). The reaction mixture was cooled to room temperature and partitioned between ice water and chloroform. The organic layer was dried over Na2SO4 and concentrated. Purification by column chromatography on silica gel (4% MeOH in CHCl3), followed by hexane and ether wash, afforded 55 mg of the product (31.97% yield).

1. temperatureThe reaction mixture was cooled to room temperature
2. custompartitioned between ice water and chloroform
3. dry with materialThe organic layer was dried over Na2SO4
4. concentrationconcentrated
5. customPurification by column chromatography on silica gel (4% MeOH in CHCl3)
6. washwash