Nitric Acid → 1-Bromo-4-nitrobenzene

HRID 80282Notes

Reaction equation

HRID 80282 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[N+:10]([O-])([OH:12])=[O:11]>ClC1C=CC=CC=1>[N+:10]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)([O-:12])=[O:11]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 7961Bromobenzene2×HCID 14798Sodium Hydroxide2×

Product 1

HCID 114661-Bromo-4-nitrobenzene

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

The bromobenzene may then be converted to phenols by a reaction with a sodium hydroxide solution, similar to the hydrolysis of chlorobenzene, with NaOH under pressure. In addition, bromobenzene may be reacted with nitric acid to form p-nitro-bromobenzene, which can then be converted after several other chemical processing steps to p-methoxyphenol. Other chemicals may be produced using bromobenzene as a raw starting material.

Sources & evidence

ORD record
ord-fa25f2473e9b417fb408c24b50f0da4d
Source dataset
uspto-grants-2014_09
Patent number
US08845876B2

Reaction notes

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