Tetrahydrofuran → tert-butyl 4-(6-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-4-hydroxypiperidine-1-carboxylate

HRID 803075Notes

Reaction equation

[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH:21]([Li:22])([CH2:23][CH3:24])[CH3:25].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]1)[n:8]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[cH:9][cH:10]2.[O:26]=[C:27]1[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:31][CH2:32]1>>[Cl:1][c:2]1[cH:3][c:4]([C:27]2([OH:26])[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:31][CH2:32]2)[c:5]2[c:6]([n:7]1)[n:8]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[cH:9][cH:10]2