1-Methylpiperazine → 2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

HRID 8031Notes

Reaction equation

HRID 8031 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:34][C:35]1[CH:36]=[C:37]([CH:61]=[CH:62][C:63]=1[F:64])[CH2:38][N:39]1[C:44](=[O:45])[C:43]([CH2:46]OS(C)(=O)=O)=[CH:42][C:41]([C:52]2[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[C:54]([F:60])[CH:53]=2)=[N:40]1.CN1CCNCC1>>[F:34][C:35]1[CH:36]=[C:37]([CH:61]=[CH:62][C:63]=1[F:64])[CH2:38][N:39]1[C:44](=[O:45])[C:43]([CH2:46][N:11]2[CH2:12][CH2:13][N:8]([CH3:6])[CH2:9][CH2:10]2)=[CH:42][C:41]([C:52]2[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[C:54]([F:60])[CH:53]=2)=[N:40]1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 21991516HCID 21991516, compoundHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 102981172-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneYield 55%

Procedure

Following the procedure of Example 1 (10), 2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as slightly-yellow neeldes (yield: 55.0%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-baf3a5ad49e947c4b1b86a6a9af2c485
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

Loading…