HRID8031

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53167

1-Methylpiperazine

C5H12N2

结构：COc1ccc(-c2cc(COS(C)(=O)=O)c(=O)n(Cc3ccc(F)c(F)c3)n2)cc1F

HCID21991516

未命名化合物

结构：Cc1ccc(-c2nn(CC(C)C)c(=O)c(N3CCN(C(=O)OC(C)(C)C)CC3)c2C)cc1F

HCID67214099

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2cc(CN3CCN(C)CC3)c(=O)n(Cc3ccc(F)c(F)c3)n2)cc1F

HCID10298117

未命名化合物

收率 55%

PROCEDURE

实验过程

Following the procedure of Example 1 (10), 2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as slightly-yellow neeldes (yield: 55.0%).

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-baf3a5ad49e947c4b1b86a6a9af2c485
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07087606B2
来源说明: uspto-grants-2006_08

反应 SMILES

C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:34][C:35]1[CH:36]=[C:37]([CH:61]=[CH:62][C:63]=1[F:64])[CH2:38][N:39]1[C:44](=[O:45])[C:43]([CH2:46]OS(C)(=O)=O)=[CH:42][C:41]([C:52]2[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[C:54]([F:60])[CH:53]=2)=[N:40]1.CN1CCNCC1>>[F:34][C:35]1[CH:36]=[C:37]([CH:61]=[CH:62][C:63]=1[F:64])[CH2:38][N:39]1[C:44](=[O:45])[C:43]([CH2:46][N:11]2[CH2:12][CH2:13][N:8]([CH3:6])[CH2:9][CH2:10]2)=[CH:42][C:41]([C:52]2[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[C:54]([F:60])[CH:53]=2)=[N:40]1