4-Chlorobenzylamine → 3-(4-Chlorobenzylamino)methylenedihydrofuran-2-one

HRID 80334Notes

Reaction equation

[Na].O[CH:3]=[C:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9].[Cl:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][NH2:16])=[CH:13][CH:12]=1>>[Cl:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][NH:16][CH:3]=[C:4]2[CH2:8][CH2:7][O:6][C:5]2=[O:9])=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 660364-Chlorobenzylamine

HCID 66988753HCID 66988753, compound

Product 1

HCID 669884303-(4-Chlorobenzylamino)methylenedihydrofuran-2-oneYield 73%

Procedure

Using 3-hydroxymethylenedihydrofuran-2-one sodium salt (10 mmol) and 4-chlorobenzylamine (11 mmol) and proceeding according to the abovementioned method A2, 3-(4-chlorobenzylamino)methylenedihydrofuran-2-one (1.5 g, 73%) is produced in the form of a white powder.

Sources & evidence

ORD record: ord-bbcd5cd95dcc48e49829a5a866f02726
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846125B2

Reaction notes

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