Dichloromethane → Trifluoroacetic acid

HRID 803786Notes

Reaction equation

HRID 803786 reaction equation
[C:1]([N:8]([C:2]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:27])[CH:9]1[CH:10]([OH:26])[CH:11]([OH:25])[CH:12]([n:14]2[c:15]3[n:16][c:17]([Cl:24])[n:18][c:19]([Cl:23])[c:20]3[n:21][cH:22]2)[CH2:13]1)([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33].[Cl:41][CH2:42][Cl:43].[F:34][C:35]([C:36](=[O:37])[OH:38])([F:39])[F:40]>>[F:34][C:35]([C:36](=[O:37])[OH:38])([F:39])[F:40].[NH2:8][CH:9]1[CH:10]([OH:26])[CH:11]([OH:25])[CH:12]([n:14]2[c:15]3[n:16][c:17]([Cl:24])[n:18][c:19]([Cl:23])[c:20]3[n:21][cH:22]2)[CH2:13]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 76602760tert-butyl N-[4-(2,6-dichloropurin-9-yl)-2,3-dihydroxycyclopentyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

Product 2

HCID 6422Trifluoroacetic acidHCID 866358313-Amino-5-(2,6-dichloropurin-9-yl)cyclopentane-1,2-diol

Sources & evidence

ORD record
ord-084e1c9602454a4cb4d6e551ebf00ac0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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