Tetrahydrofuran → 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

HRID 803895Notes

Reaction equation

HRID 803895 reaction equation
[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH3:44][CH2:45][CH2:46][CH2:47][Li:48].[Cl:1][c:2]1[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([S:16]([CH3:17])(=[O:18])=[O:19])[CH2:20][CH2:21]1)[s:10]2.[Cl:28][c:29]1[n:30][c:31]([N:32]2[CH2:33][CH2:34][O:41][CH2:35][CH2:36]2)[c:37]2[s:38][cH:39][cH:40][c:42]2[n:43]1>>[Cl:1][c:2]1[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH:11]=[O:41])[s:10]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 202849712-Chloro-4-(morpholin-4-yl)thieno(3,2-d)pyrimidineHCID 236508374-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholineHCID 178418339Butyllithium

Product 1

HCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Sources & evidence

ORD record
ord-80400f1136de4727ab1e6d1abea90373
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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