4-(Difluoromethoxy)benzyl Bromide → 2-(3-(4-(difluoromethoxy)benzyl)-2-oxopyrrolidin-1-yl)-N-(4-fluorobenzyl)-4-methylthiazole-5-carboxamide
Reaction equation
[Br:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([O:9][CH:10]([F:11])[F:12])[cH:7][cH:8]1.[F:13][c:14]1[cH:15][cH:16][c:17]([CH2:18][NH:19][C:20](=[O:21])[c:22]2[c:23]([CH3:33])[n:24][c:25]([N:27]3[C:28](=[O:32])[CH2:29][CH2:30][CH2:31]3)[s:26]2)[cH:34][cH:35]1>>[CH2:2]([c:3]1[cH:4][cH:5][c:6]([O:9][CH:10]([F:11])[F:12])[cH:7][cH:8]1)[CH:29]1[C:28](=[O:32])[N:27]([c:25]2[n:24][c:23]([CH3:33])[c:22]([C:20]([NH:19][CH2:18][c:17]3[cH:16][cH:15][c:14]([F:13])[cH:35][cH:34]3)=[O:21])[s:26]2)[CH2:31][CH2:30]1Participants
3
Sources & evidence
- ORD record
- ord-c61ec8b5919a4685a3900c37f463526e
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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