2-(Trifluoromethylthio)ethyl Trifluoromethanesulfonate → 4-Trifluoromethylsulfanyl-2-(3,3,3-trifluoro-2-methyl-2-trifluoromethyl-propane-1-sulfonyl)-butyronitrile

HRID 80412Notes

Reaction equation

HRID 80412 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]([CH3:15])([C:11]([F:14])([F:13])[F:12])[CH2:4][S:5]([CH2:8][C:9]#[N:10])(=[O:7])=[O:6].[F:18][C:19]([S:22][CH2:23][CH2:24]OS(C(F)(F)F)(=O)=O)([F:21])[F:20]>>[F:18][C:19]([S:22][CH2:23][CH2:24][CH:8]([S:5]([CH2:4][C:3]([CH3:15])([C:2]([F:1])([F:16])[F:17])[C:11]([F:13])([F:12])[F:14])(=[O:6])=[O:7])[C:9]#[N:10])([F:21])[F:20]

Participants

3

Reactant 2

HCID 252420282-(Trifluoromethylthio)ethyl TrifluoromethanesulfonateHCID 86673277(3,3,3-Trifluoro-2-methyl-2-trifluoromethyl-propane-1-sulfonyl)-acetonitrile

Product 1

HCID 866732764-Trifluoromethylsulfanyl-2-(3,3,3-trifluoro-2-methyl-2-trifluoromethyl-propane-1-sulfonyl)-butyronitrile

Procedure

Compound II-28 was prepared from (3,3,3-trifluoro-2-methyl-2-trifluoromethyl-propane-1-sulfonyl)-acetonitrile and trifluoro-methanesulfonic acid 2-trifluoromethylsulfanyl-ethyl ester as described for compound II-1.

Sources & evidence

ORD record
ord-dc3cb636aada45639f626529edb5439d
Source dataset
uspto-grants-2014_09
Patent number
US08846569B2

Reaction notes

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