Hydrochloric Acid → 2,3,3'-Trifluoro-4'-hydroxy-4-propylbiphenyl

HRID 804136Notes

Reaction equation

HRID 804136 reaction equation
[CH3:51][OH:52].[ClH:49].[F:1][c:2]1[c:3](-[c:12]2[cH:13][c:14]([F:22])[c:15]([O:18][CH2:19][O:20][CH3:21])[cH:16][cH:17]2)[cH:4][cH:5][c:6]([CH2:9][CH2:10][CH3:11])[c:7]1[F:8].[F:23][c:24]1[c:25]([F:26])[c:27]([CH2:28][CH2:29][CH3:30])[cH:31][cH:32][c:33]1[I:34].[OH2:50].[OH:35][B:36]([OH:37])[c:38]1[cH:39][cH:40][c:41]([O:42][CH2:43][O:44][CH3:45])[c:46]([F:47])[cH:48]1>>[F:1][c:2]1[c:3](-[c:12]2[cH:13][c:14]([F:22])[c:15]([OH:18])[cH:16][cH:17]2)[cH:4][cH:5][c:6]([CH2:9][CH2:10][CH3:11])[c:7]1[F:8]

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 220080752,3,3'-Trifluoro-4'-methoxymethoxy-4-propylbiphenylHCID 22008077(3-Fluoro-4-(methoxymethoxy)phenyl)boronic acidHCID 220080842,3-Difluoro-1-iodo-4-propylbenzene

Product 1

HCID 220080852,3,3'-Trifluoro-4'-hydroxy-4-propylbiphenyl

Sources & evidence

ORD record
ord-35f70d758ebc44deaeb9b2bb3318bd63
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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