HCID 68178824, compound → HCID 68178774, compound

HRID 80414Notes

Reaction equation

HRID 80414 reaction equation
C([O:8][C@H:9]1[C@H:14]([O:15]CC2C=CC=CC=2)[C@@H:13]([CH2:23][O:24][P:25]([OH:28])([OH:27])=[O:26])[CH2:12][C@H:11]([OH:29])[C@@H:10]1[NH:30]CC1C=CC=CC=1)C1C=CC=CC=1>CO.[Pd]>[NH2:30][C@@H:10]1[C@@H:9]([OH:8])[C@H:14]([OH:15])[C@@H:13]([CH2:23][O:24][P:25]([OH:28])([OH:27])=[O:26])[CH2:12][C@@H:11]1[OH:29]

Participants

4

Reactant 1

HCID 68178824HCID 68178824, compound

Product 1

HCID 68178774HCID 68178774, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 40 mg of the compound of step 1.3 (0.068 mmol) in MeOH (2 mL) was added 10% Pd on carbon catalyst (10 mg) and the mixture was vigorously stirred under a hydrogen atmosphere (1 atm) at room temperature for 4 h. After filtration and lyophilization, the titled compound was obtained as a colorless solid (16 mg, 98%).

Workup

  1. filtrationAfter filtration and lyophilization

Sources & evidence

ORD record
ord-5a6f9d42fb90485f956684be2b831813
Source dataset
uspto-grants-2014_09
Patent number
US08846645B2

Reaction notes

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