Dichloromethane → 8-(2-Fluorophenyl)-7-methoxy-4-[3-(1,2,4-triazol-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one

HRID 804579Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[cH:9][c:10]([O:38][CH3:39])[c:11](-[c:31]2[c:32]([F:37])[cH:33][cH:34][cH:35][cH:36]2)[cH:12][c:13]1[NH:14][C:15]([CH2:16][C:17](=[O:5])[c:18]1[cH:19][c:20](-[n:24]2[cH:25][n:26][n:27][cH:28]2)[cH:21][cH:22][cH:23]1)=[O:30])([CH3:6])([CH3:29])[CH3:40].[Cl:48][CH2:49][Cl:50].[F:41][C:42]([F:43])([F:44])[C:45]([OH:46])=[O:47]>>[N:7]1=[C:17]([c:18]2[cH:19][c:20](-[n:24]3[cH:25][n:26][n:27][cH:28]3)[cH:21][cH:22][cH:23]2)[CH2:16][C:15](=[O:30])[NH:14][c:13]2[c:8]1[cH:9][c:10]([O:38][CH3:39])[c:11](-[c:31]1[c:32]([F:37])[cH:33][cH:34][cH:35][cH:36]1)[cH:12]2

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 86758248tert-butyl N-[4-(2-fluorophenyl)-5-methoxy-2-[[3-oxo-3-[3-(1,2,4-triazol-4-yl)phenyl]propanoyl]amino]phenyl]carbamate

Product 1

HCID 224486928-(2-Fluorophenyl)-7-methoxy-4-[3-(1,2,4-triazol-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one

Sources & evidence

ORD record: ord-70a74c89bc8347dcaf99c8f4502d8af7
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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