Methanol → 4-(5-Amino-thiophen-2-yl)-butyric acid methyl ester

HRID 804597Notes

Reaction equation

HRID 804597 reaction equation
[CH3:16][CH2:17][O:18][C:19](=[O:20])[CH3:21].[CH3:1][O:2][C:3]([CH2:4][CH2:5][CH2:6][c:7]1[s:8][c:9]([N+:12]([O-:13])=[O:14])[cH:10][cH:11]1)=[O:15].[CH3:22][OH:23].[OH-:24].[OH-:26].[Pd+2:25]>>[CH3:1][O:2][C:3]([CH2:4][CH2:5][CH2:6][c:7]1[s:8][c:9]([NH2:12])[cH:10][cH:11]1)=[O:15]

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 692334004-(5-Nitro-thiophen-2-yl)-butyric acid methyl ester

Product 1

HCID 692355624-(5-Amino-thiophen-2-yl)-butyric acid methyl ester

Sources & evidence

ORD record
ord-f904fed4d5fb451e9affb78d9ecac24d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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