Dichloromethane → (4-Chloro-5-fluoro-3-methoxypyridin-2-yl)cyclopropylacetonitrile

HRID 804603Notes

Reaction equation

HRID 804603 reaction equation
[C:1]([O:2][c:6]1[c:7]([O:19][CH3:20])[c:8]([CH:13]([C:14]#[N:15])[CH:16]2[CH2:17][CH2:18]2)[n:9][cH:10][c:11]1[F:12])([CH3:3])([CH3:4])[CH3:5].[Cl:28][CH2:29][Cl:30].[OH:21][C:22]([C:23]([F:24])([F:25])[F:26])=[O:27]>>[c:6]1([Cl:28])[c:7]([O:19][CH3:20])[c:8]([CH:13]([C:14]#[N:15])[CH:16]2[CH2:17][CH2:18]2)[n:9][cH:10][c:11]1[F:12]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 10707715(4-tert-Butoxy-5-fluoro-3-methoxypyridin-2-yl)cyclopropylacetonitrile

Product 1

HCID 10562063(4-Chloro-5-fluoro-3-methoxypyridin-2-yl)cyclopropylacetonitrile

Sources & evidence

ORD record
ord-dce675ac6c3c4d75ad138fd9e98c547d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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