Chloroform → Trifluoroacetic acid

HRID 804604Notes

Reaction equation

HRID 804604 reaction equation
[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13]([C:14]([CH2:15][CH2:16][CH2:17][Cl:18])=[CH:19][c:20]1[cH:21][c:22]([F:32])[c:23](-[n:26]2[cH:27][n:28][c:29]([CH3:31])[cH:30]2)[cH:24][cH:25]1)=[O:33].[CH:34]([Cl:35])([Cl:36])[Cl:37].[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7]>>[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7].[O:12]=[C:13]([C:14]([CH2:15][CH2:16][CH2:17][Cl:18])=[CH:19][c:20]1[cH:21][c:22]([F:32])[c:23](-[n:26]2[cH:27][n:28][c:29]([CH3:31])[cH:30]2)[cH:24][cH:25]1)[OH:33]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 6422Trifluoroacetic acidHCID 77588505Tert-butyl 5-chloro-2-[[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]methylidene]pentanoate

Product 2

HCID 6422Trifluoroacetic acidHCID 690031855-Chloro-2-[[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]methylidene]pentanoic acid

Sources & evidence

ORD record
ord-722c572d350f49a485f935f40935f544
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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