Bicarbonate Ion → N-(cyanomethyl)-4-methyl-2-{[4'-(1-piperazinyl)[1,1'-biphenyl]-2-yl]methyl}pentanamide

HRID 804660Notes

Reaction equation

HRID 804660 reaction equation
[C:1](#[N:2])[CH2:3][NH:4][C:5](=[O:6])[CH:7]([CH2:8][c:9]1[c:10](-[c:15]2[cH:16][cH:17][c:18]([N:21]3[CH2:22][CH2:23][N:24]([C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33])[CH2:25][CH2:26]3)[cH:19][cH:20]2)[cH:11][cH:12][cH:13][cH:14]1)[CH2:34][CH:35]([CH3:36])[CH3:37].[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[Na+:42].[O-:38][C:39]([OH:40])=[O:41]>>[C:1](#[N:2])[CH2:3][NH:4][C:5](=[O:6])[CH:7]([CH2:8][c:9]1[c:10](-[c:15]2[cH:16][cH:17][c:18]([N:21]3[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]3)[cH:19][cH:20]2)[cH:11][cH:12][cH:13][cH:14]1)[CH2:34][CH:35]([CH3:36])[CH3:37]

Participants

5

Reactant 4

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 8028TetrahydrofuranHCID 22235962Tert-butyl 4-[2'-(2-{[(cyanomethyl)amino]carbonyl}-4-methylpentyl)[1,1'-biphenyl]-4-yl]-1-piperazinecarboxylate

Product 1

HCID 10158123N-(cyanomethyl)-4-methyl-2-{[4'-(1-piperazinyl)[1,1'-biphenyl]-2-yl]methyl}pentanamide

Sources & evidence

ORD record
ord-e0ec8937b02642ebb0135f60486d5032
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…