HRID80469

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6367

Acetyl chloride

C2H3ClO

HCID8471

Triethylamine

C6H15N

结构：COc1ccc(Cn2c(=O)c3cc(OCc4ccccc4)ccc3n(C3CCNCC3)c2=O)cc1OC

HCID66603393

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Cn2c(=O)c3cc(OCc4ccccc4)ccc3n(C3CCN(C(C)=O)CC3)c2=O)cc1OC

HCID59587162

未命名化合物

收率 98.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度: 0 °C

PROCEDURE

实验过程

0.14 g of acetyl chloride is added to a mixture of 0.6 g of 6-(benzyloxy)-3-(3,4-dimethoxybenzyl)-1-(piperidin-4-yl)quinazoline-2,4(1H,3H)-dione obtained according to stage 1.6 and 0.24 g of NEt3 in 10 ml of DCM cooled to 0° C. The mixture is stirred at AT overnight. It is washed twice with a saturated NH4Cl solution and filtered, and then the filtrate is evaporated under reduced pressure to give 0.64 g of the expected product.

WORKUP

后处理

customobtained
washIt is washed twice with a saturated NH4Cl solution
filtrationfiltered
customthe filtrate is evaporated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-41c3398167844ac1981104c69988413d
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846654B2
来源说明: uspto-grants-2014_09

反应 SMILES

[C:1](Cl)(=[O:3])[CH3:2].[CH2:5]([O:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]([CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[C:18](=[O:29])[N:17]([CH2:30][C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([O:39][CH3:40])[CH:32]=1)[C:16]2=[O:41])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.CCN(CC)CC>C(Cl)Cl>[C:1]([N:26]1[CH2:27][CH2:28][CH:23]([N:19]2[C:20]3[C:15](=[CH:14][C:13]([O:12][CH2:5][C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=4)=[CH:22][CH:21]=3)[C:16](=[O:41])[N:17]([CH2:30][C:31]3[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([O:39][CH3:40])[CH:32]=3)[C:18]2=[O:29])[CH2:24][CH2:25]1)(=[O:3])[CH3:2]