Acetic Acid → 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyridin-4-yl-urea

HRID 804767Notes

Reaction equation

HRID 804767 reaction equation
[BrH:50].[CH2:1]([O:2][C:3](=[O:4])[N:11]1[CH:12]([CH2:17][CH2:18][O:19][c:20]2[c:21](-[c:42]3[cH:43][c:44]([CH3:49])[cH:45][c:46]([CH3:48])[cH:47]3)[c:22](=[O:41])[nH:23][c:24]3[cH:25][c:26]([Cl:40])[c:27]([NH:30][C:31](=[O:32])[NH:33][c:34]4[cH:35][cH:36][n:37][cH:38][cH:39]4)[cH:28][c:29]23)[CH2:13][CH2:14][CH2:15][CH2:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:51][C:52](=[O:53])[OH:54]>>[NH:11]1[CH:12]([CH2:17][CH2:18][O:19][c:20]2[c:21](-[c:42]3[cH:43][c:44]([CH3:49])[cH:45][c:46]([CH3:48])[cH:47]3)[c:22](=[O:41])[nH:23][c:24]3[cH:25][c:26]([Cl:40])[c:27]([NH:30][C:31](=[O:32])[NH:33][c:34]4[cH:35][cH:36][n:37][cH:38][cH:39]4)[cH:28][c:29]23)[CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 543905802-{2-[7-Chloro-3-(3,5-dimethylphenyl)-2-oxo-6-(3-pyridin-4-yl-ureido)-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester

Product 1

HCID 99591211-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyridin-4-yl-urea

Sources & evidence

ORD record
ord-4fb4ec5016924de4a039c7f8982f1a4b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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