反应详情

温度

85 °C

A round bottom flask was charged with methyl 2-(4-benzyl-1-(5-chloro-2-nitrophenyl)piperazin-2-yl)acetate (Example 24A, 19.4 g, 48.0 mmol) and iron (8.05 g, 144 mmol) followed by acetic acid (70 mL). The solution was heated at 85° C. for 2 hours. The solution was concentrated onto silica gel, and eluted through a silica column (0-10% methanol/dichloromethane). The product was then concentrated and redissolved in dichloromethane. Addition of sodium hydroxide (1M) caused the title compound to precipitate. 1H NMR (300 MHz, DMSO-d6) δ ppm 9.56 (s, 1H), 7.22-7.40 (m, 5H) 7.00-7.09 (m, 2H), 6.88-6.96 (m, 1H), 3.54 (s, 2H), 3.07-3.21 (m, 1H), 2.94-3.05 (m, 1H), 2.71-2.87 (m, 2H), 2.52-2.61 (m, 1H), 2.04-2.27 (m, J=10.71 Hz, 2H), 1.84-1.95 (m, 2H); MS (ESI) m/z 341.9 (M+H)+.

1. concentrationThe solution was concentrated onto silica gel
2. washeluted through a silica column (0-10% methanol/dichloromethane)
3. concentrationThe product was then concentrated
4. dissolutionredissolved in dichloromethane
5. additionAddition of sodium hydroxide (1M)
6. customto precipitate