Dichloromethane → [(3-{1-[(cyclopropylmethyl)amino]-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl}-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)oxy]acetic acid

HRID 805078Notes

Reaction equation

[CH:1]1([CH2:4][NH:5][n:6]2[c:7](=[O:38])[c:8]([C:17]3=[N:18][S:19](=[O:36])(=[O:37])[c:20]4[c:21]([cH:23][cH:24][c:25]([O:27][CH2:28][C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[cH:26]4)[NH:22]3)[c:9]([OH:16])[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]23)[CH2:2][CH2:3]1.[Cl:46][CH2:47][Cl:48].[OH:39][C:40]([C:41]([F:42])([F:43])[F:44])=[O:45]>>[CH:1]1([CH2:4][NH:5][n:6]2[c:7](=[O:38])[c:8]([C:17]3=[N:18][S:19](=[O:36])(=[O:37])[c:20]4[c:21]([cH:23][cH:24][c:25]([O:27][CH2:28][C:29](=[O:30])[OH:31])[cH:26]4)[NH:22]3)[c:9]([OH:16])[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]23)[CH2:2][CH2:3]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 136358498tert-butyl [(3-{1-[(cyclopropylmethyl)amino]-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl}-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)oxy]acetate

Product 1

HCID 136358499[(3-{1-[(cyclopropylmethyl)amino]-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl}-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl)oxy]acetic acid

Sources & evidence

ORD record: ord-3ad65c2bb9654dbebef7de408df6f1a2
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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