Hydrochloric Acid → Lenvatinib Impurity F

HRID 805084Notes

Reaction equation

HRID 805084 reaction equation
[CH3:35][OH:36].[Cl:3][c:4]1[cH:5][c:6]([O:7][c:8]2[cH:9][cH:10][n:11][c:12]3[cH:13][c:14]([O:22][CH3:23])[c:15]([C:18](=[O:19])[O:20][CH3:21])[cH:16][c:17]23)[cH:24][cH:25][c:26]1[NH:27][C:28](=[O:29])[NH:30][CH:31]1[CH2:32][CH2:33]1.[ClH:34].[Na+:2].[OH-:1]>>[Cl:3][c:4]1[cH:5][c:6]([O:7][c:8]2[cH:9][cH:10][n:11][c:12]3[cH:13][c:14]([O:22][CH3:23])[c:15]([C:18](=[O:19])[OH:20])[cH:16][c:17]23)[cH:24][cH:25][c:26]1[NH:27][C:28](=[O:29])[NH:30][CH:31]1[CH2:32][CH2:33]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 22936518Methyl 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxylate

Product 1

HCID 22936749Lenvatinib Impurity F

Sources & evidence

ORD record
ord-978ac26cadc941219a656cf85df3b771
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…