Acetone → [4-(1,4-Benzodioxan-5-yl)-1,2,3,6-tetrahydropyrid-1-yl]acetonitrile

HRID 805211Notes

Reaction equation

HRID 805211 reaction equation
[Br:7][CH2:8][C:9]#[N:10].[C:1](=[O:2])([O-:3])[O-:4].[CH3:28][C:29](=[O:30])[CH3:31].[ClH:11].[K+:5].[K+:6].[O:12]1[CH2:13][CH2:14][O:15][c:16]2[c:17]1[cH:18][cH:19][cH:20][c:21]2[C:22]1=[CH:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[CH2:8]([C:9]#[N:10])[N:25]1[CH2:24][CH2:23][C:22]([c:21]2[c:16]3[c:17]([cH:18][cH:19][cH:20]2)[O:12][CH2:13][CH2:14][O:15]3)=[CH:27][CH2:26]1

Participants

7

Reactant 6

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 11534BromoacetonitrileHCID 19660Carbonate IonHCID 190962394-(2,3-Dihydro-1,4-benzodioxin-5-yl)-1,2,3,6-tetrahydropyridine

Product 1

HCID 19105274[4-(1,4-Benzodioxan-5-yl)-1,2,3,6-tetrahydropyrid-1-yl]acetonitrile

Sources & evidence

ORD record
ord-f7f9b5d90428422792f2a5ffd4fb3552
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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