Dichloromethane → 4-[2,3']Bipyridinyl-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 805364Notes

Reaction equation

HRID 805364 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[c:9]([NH:18][C:19]([CH2:20][C:21](=[O:5])[c:23]2[cH:24][c:25](-[c:29]3[cH:30][n:31][cH:32][cH:33][cH:34]3)[n:26][cH:27][cH:28]2)=[O:35])[cH:10][c:11]([C:14]([F:15])([F:16])[F:17])[cH:12][cH:13]1)([CH3:6])([CH3:22])[CH3:36].[Cl:44][CH2:45][Cl:46].[F:37][C:38]([F:39])([F:40])[C:41]([OH:42])=[O:43]>>[N:7]1=[C:21]([c:23]2[cH:24][c:25](-[c:29]3[cH:30][n:31][cH:32][cH:33][cH:34]3)[n:26][cH:27][cH:28]2)[CH2:20][C:19](=[O:35])[NH:18][c:9]2[c:8]1[cH:13][cH:12][c:11]([C:14]([F:15])([F:16])[F:17])[cH:10]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 86589463[2-(3-[2,3']Bipyridinyl-4-yl-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 223174004-[2,3']Bipyridinyl-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Sources & evidence

ORD record
ord-89c3e9fd7ad24f8ea55d5891817c9070
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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