Dimethylacetamide → 4-[2,3-Difluoro-4-(propane-2-sulfonyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

HRID 805543Notes

Reaction equation

HRID 805543 reaction equation
[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]1.[CH3:29][N:30]([CH3:31])[C:32](=[O:33])[CH3:34].[F:1][c:2]1[c:3]([F:15])[c:4]([F:14])[c:5]([S:8](=[O:9])(=[O:10])[CH:11]([CH3:12])[CH3:13])[cH:6][cH:7]1>>[c:2]1([N:26]2[CH2:25][CH2:24][N:23]([C:21]([O:20][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:22])[CH2:28][CH2:27]2)[c:3]([F:15])[c:4]([F:14])[c:5]([S:8](=[O:9])(=[O:10])[CH:11]([CH3:12])[CH3:13])[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 31374DimethylacetamideHCID 143452tert-Butyl piperazine-1-carboxylateHCID 690368531,2,3-Trifluoro-4-(propane-2-sulfonyl)-benzene

Product 1

HCID 690416594-[2,3-Difluoro-4-(propane-2-sulfonyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-fc5dc35e242b41b39149f9b68ea2fd66
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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