HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 67008171, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 7-Bromo-8-methylpyrido[2,3-b]pyrazine | HCID 33726435 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67008171 | HCID 67008171 | 56.1% |
Reaction Steps
7-bromo-8-methylpyrido[2,3-b]pyrazine (0.21 g) and NaBH4 (0.21 g) in THF (1.4 ml) was treated with trifluoroacetic acid (1.4 ml) at room temperature over a period of 15 min. Stirring continued for additional 45 min then water was added followed by 50% sodium hydroxide. The residue was extracted into CH2Cl2, filtered, dried, and concentrated to furnish the desired product (0.12 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846664B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-28962435aa10417fab0a09a8489ecd86 |
| Source note | uspto-grants-2014_09 |