HCID 44119394, compound → 3-[9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepin-2-yl]-N-[2-(morpholin-4-yl)ethyl]benzamide

HRID 80567Notes

Reaction equation

HRID 80567 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[NH:11][CH2:10][CH2:9][CH2:8][N:7]([CH2:12][C:13]3[C:18]([F:19])=[CH:17][CH:16]=[C:15]([F:20])[C:14]=3[Cl:21])[C:6]=2[N:22]=1.[O:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][NH:31][C:32]([C:34]2[CH:35]=[C:36](B(O)O)[CH:37]=[CH:38][CH:39]=2)=[O:33])[CH2:25][CH2:24]1>>[Cl:21][C:14]1[C:15]([F:20])=[CH:16][CH:17]=[C:18]([F:19])[C:13]=1[CH2:12][N:7]1[CH2:8][CH2:9][CH2:10][NH:11][C:5]2[N:4]=[CH:3][C:2]([C:38]3[CH:39]=[C:34]([CH:35]=[CH:36][CH:37]=3)[C:32]([NH:31][CH2:30][CH2:29][N:26]3[CH2:25][CH2:24][O:23][CH2:28][CH2:27]3)=[O:33])=[N:22][C:6]1=2

Participants

3

Reactant 2

HCID 44119394HCID 44119394, compoundHCID 866594302-Bromo-9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepine

Product 1

HCID 670081683-[9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepin-2-yl]-N-[2-(morpholin-4-yl)ethyl]benzamide

Procedure

The entitled compound can be prepared from 2-Bromo-9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepine and 3-(2-morpholinoethylcarbamoyl)phenyl boronic acid as described in example 1 or 30.

Sources & evidence

ORD record
ord-817a2a8473f54f54926fec4310af673e
Source dataset
uspto-grants-2014_09
Patent number
US08846664B2

Reaction notes

Loading…