HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-(2-Hydroxyethyl)piperazine-1-carbonyl)phenylboronic acid → {3-[9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepin-2-yl]phenyl}[4-(2-hydroxyethyl)piperazin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-(2-Hydroxyethyl)piperazine-1-carbonyl)phenylboronic acid | HCID 44119390 | — |
| Reactant | 2-Bromo-9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepine | HCID 86659430 | — |
| Product | {3-[9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepin-2-yl]phenyl}[4-(2-hydroxyethyl)piperazin-1-yl]-methanone | HCID 67008019 | — |
Reaction Steps
The entitled compound can be prepared from 2-Bromo-9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepine and 3-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenylboronic acid as described in example 1 or 30.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846664B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-1ce56ef086d145a6ba8e613dc0941e57 |
| Source note | uspto-grants-2014_09 |