Isopropanol → N-((1R,2S,5R)-5-(tert-Butylamino)-2-((S)-2-oxo-3-((6-(trifluoromethyl)quinazolin-4-yl)amino)pyrrolidin-1-yl)cyclohexyl)acetamide

HRID 805792Notes

Reaction equation

HRID 805792 reaction equation
[CH:38]([OH:39])([CH3:40])[CH3:41].[Cl:23][c:24]1[n:25][cH:26][n:27][c:28]2[cH:29][cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][c:33]12.[NH2:1][CH:2]1[C:3](=[O:22])[N:4]([CH:7]2[CH:8]([NH:18][C:19]([CH3:20])=[O:21])[CH2:9][CH:10]([NH:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:11][CH2:12]2)[CH2:5][CH2:6]1>>[NH:1]([CH:2]1[C:3](=[O:22])[N:4]([CH:7]2[CH:8]([NH:18][C:19]([CH3:20])=[O:21])[CH2:9][CH:10]([NH:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:11][CH2:12]2)[CH2:5][CH2:6]1)[c:24]1[n:25][cH:26][n:27][c:28]2[cH:29][cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][c:33]12

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 210750954-Chloro-6-(trifluoromethyl)quinazolineHCID 67073895N-[2-(3-amino-2-oxopyrrolidin-1-yl)-5-(tert-butylamino)cyclohexyl]acetamide

Product 1

HCID 74109150N-((1R,2S,5R)-5-(tert-Butylamino)-2-((S)-2-oxo-3-((6-(trifluoromethyl)quinazolin-4-yl)amino)pyrrolidin-1-yl)cyclohexyl)acetamide

Sources & evidence

ORD record
ord-098786c185514d328b6baa7bfe7a4d96
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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