tert-butyl 2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-methyl-7-oxo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(9H)-yl]carbonyl}amino)propyl]benzoate → HCID 178456081, compound

HRID 80591Notes

Reaction equation

HRID 80591 reaction equation
NC1C=C([C@H](NC(N2C(=O)[C@@H](CC3C=C(Cl)C=CC=3OC)CN3C(C)=NN=C3C2)=O)CC)C=CC=1C(OC(C)(C)C)=O.[Cl:43][C:44]1[CH:45]=[CH:46][C:47]([O:82][CH3:83])=[C:48]([CH:81]=1)[CH2:49][C@H:50]1[CH2:56][N:55]2[C:57]([OH:60])=[N:58][N:59]=[C:54]2[CH2:53][N:52]([C:61]([NH:63][C@@H:64]([C:67]2[CH:68]=[C:69]([CH:77]=[CH:78][CH:79]=2)[C:70]([O:72]C(C)(C)C)=[O:71])[CH2:65][CH3:66])=[O:62])[C:51]1=[O:80]>>[Cl:43][C:44]1[CH:45]=[CH:46][C:47]([O:82][CH3:83])=[C:48]([CH:81]=1)[CH2:49][C@H:50]1[CH2:56][N:55]2[C:57]([OH:60])=[N:58][N:59]=[C:54]2[CH2:53][N:52]([C:61]([NH:63][C@@H:64]([C:67]2[CH:68]=[C:69]([CH:77]=[CH:78][CH:79]=2)[C:70]([OH:72])=[O:71])[CH2:65][CH3:66])=[O:62])[C:51]1=[O:80]

Participants

3

Reactant 2

HCID 86672194tert-butyl 2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-methyl-7-oxo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(9H)-yl]carbonyl}amino)propyl]benzoateHCID 178456082tert-butyl 3-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-hydroxy-7-oxo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(9H)-yl]carbonyl}amino)propyl]benzoate

Product 1

HCID 178456081HCID 178456081, compound

Procedure

Instead of the starting material of Example 87, Step (3), that is, the compound 87b, the compound 92a was used for a similar procedure as in Example 87, Step (3) to obtain the title compound.

Sources & evidence

ORD record
ord-5b18954b1f1a4006ba7ec9dd50f5cc63
Source dataset
uspto-grants-2014_09
Patent number
US08846660B2

Reaction notes

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