tert-butyl 3-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-hydroxy-7-oxo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(9H)-yl]carbonyl}amino)propyl]benzoate → 3-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-2-ethyl-3,7-dioxo-2,6,7,9-tetrahydro-3H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(5H)-yl]carbonyl}amino)propyl]benzoic acid
Reaction equation
Cl[C:2]1C=CC(OC)=C([CH:42]=1)C[C@H]1CN2C(O)=NN=C2CN(C(N[C@@H](C2C=CC(C(OC(C)(C)C)=O)=C([N+]([O-])=O)C=2)CC)=O)C1=O.[Cl:45][C:46]1[CH:47]=[CH:48][C:49]([O:84][CH3:85])=[C:50]([CH:83]=1)[CH2:51][C@H:52]1[CH2:58][N:57]2[C:59]([OH:62])=[N:60][N:61]=[C:56]2[CH2:55][N:54]([C:63]([NH:65][C@@H:66]([C:69]2[CH:70]=[C:71]([CH:79]=[CH:80][CH:81]=2)[C:72]([O:74]C(C)(C)C)=[O:73])[CH2:67][CH3:68])=[O:64])[C:53]1=[O:82]>>[Cl:45][C:46]1[CH:47]=[CH:48][C:49]([O:84][CH3:85])=[C:50]([CH:83]=1)[CH2:51][C@H:52]1[CH2:58][N:57]2[C:59](=[O:62])[N:60]([CH2:2][CH3:42])[N:61]=[C:56]2[CH2:55][N:54]([C:63]([NH:65][C@@H:66]([C:69]2[CH:70]=[C:71]([CH:79]=[CH:80][CH:81]=2)[C:72]([OH:74])=[O:73])[CH2:67][CH3:68])=[O:64])[C:53]1=[O:82]Participants
3
Reactant 2
Product 1
Procedure
Instead of the starting material, that is, the compound 91a, of Example 91, Step (2), the compound 92a was used for a similar procedure as in Example 91, Step (2) and Example 87, Step (3) to obtain the title compound.
Sources & evidence
- ORD record
- ord-3fab7c3ba9b34f2e81c026a2bf6cfddc
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846660B2
Reaction notes
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