tert-butyl 3-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-hydroxy-7-oxo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(9H)-yl]carbonyl}amino)propyl]benzoate → 3-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-2-ethyl-3,7-dioxo-2,6,7,9-tetrahydro-3H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(5H)-yl]carbonyl}amino)propyl]benzoic acid

Participants

Role	Name	HCID	Charge
Reactant	tert-butyl 3-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-hydroxy-7-oxo-6,7-dihydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(9H)-yl]carbonyl}amino)propyl]benzoate	HCID 178456082	—
Reactant	HCID 178456083	HCID 178456083	—
Product	3-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-2-ethyl-3,7-dioxo-2,6,7,9-tetrahydro-3H-[1,2,4]triazolo[4,3-a][1,4]diazepin-8(5H)-yl]carbonyl}amino)propyl]benzoic acid	HCID 70815240	—

Reaction Steps

Instead of the starting material, that is, the compound 91a, of Example 91, Step (2), the compound 92a was used for a similar procedure as in Example 91, Step (2) and Example 87, Step (3) to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846660B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-3fab7c3ba9b34f2e81c026a2bf6cfddc
Source note	uspto-grants-2014_09