Pyridine → 2,2,2-Trichloroethyl [2-(acetylamino)pyrimidin-5-yl]carbamate

HRID 805938Notes

Reaction equation

HRID 805938 reaction equation
[Cl:18][C:19](=[O:20])[O:21][CH2:22][C:23]([Cl:24])([Cl:25])[Cl:26].[NH2:1][c:2]1[cH:3][n:4][c:5]([NH:8][C:9]([CH3:10])=[O:11])[n:6][cH:7]1.[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1.[cH:12]1[cH:13][cH:14][n:15][cH:16][cH:17]1>>[NH:1]([c:2]1[cH:3][n:4][c:5]([NH:8][C:9]([CH3:10])=[O:11])[n:6][cH:7]1)[C:19](=[O:20])[O:21][CH2:22][C:23]([Cl:24])([Cl:25])[Cl:26]

Participants

5

Reactant 4

HCID 1049PyridineHCID 8028TetrahydrofuranHCID 870632,2,2-Trichloroethyl chloroformateHCID 20387481N-(5-aminopyrimidin-2-yl)acetamide

Product 1

HCID 866254942,2,2-Trichloroethyl [2-(acetylamino)pyrimidin-5-yl]carbamate

Sources & evidence

ORD record
ord-351c3cce86034b918e9c0092ced36673
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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