反应详情

The product is prepared according to the procedure described in Example 22, using 100 mg of (8S)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one, 214 mg of caesium carbonate and 68 mg of 1-(bromomethyl)-3-fluorobenzene. After purification by preparative HPLC/MS (Method C), 102 mg of (8S)-9-(3-fluorobenzyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]-pyrimidin-4-one are obtained in the form of an oil, the characteristics of which are the following:

1. customThe product is prepared
2. customAfter purification by preparative HPLC/MS (Method C), 102 mg of (8S)-9-(3-fluorobenzyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]-pyrimidin-4-one
3. customare obtained in the form of an oil