Cesium carbonate → (8S)-9-(3-fluorobenzyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

Participants

Role	Name	HCID	Charge
Reactant	Cesium carbonate	HCID 10796	—
Reactant	3-Fluorobenzyl bromide	HCID 68007	—
Reactant	(S)-8-(Morpholin-4-yl)-2-(trifluoromethyl)-1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-6-one	HCID 136238743	—
Product	(8S)-9-(3-fluorobenzyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one	HCID 49854197	—

Reaction Steps

The product is prepared according to the procedure described in Example 22, using 100 mg of (8S)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one, 214 mg of caesium carbonate and 68 mg of 1-(bromomethyl)-3-fluorobenzene. After purification by preparative HPLC/MS (Method C), 102 mg of (8S)-9-(3-fluorobenzyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]-pyrimidin-4-one are obtained in the form of an oil, the characteristics of which are the following:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846670B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-498b437b30484c9fbaf0e6d8a33f2775
Source note	uspto-grants-2014_09