反应详情

To a solution of 3,5-dimethyl-1-(2-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (0.4 g) in a solution of equal proportions of ethanol and ethyl acetate was added 5% Pd/C (37 mg). The solution was treated with hydrogen gas at 45 psi. Upon completion of the reaction, the mixture was filtered through Celite, then the filtrate concentrated under vacuum. The named product was collected as an oil, which then was purified by flash chromatography to provide a solid product having a melting point of 59° C.–61° C.

1. customUpon completion of the reaction
2. filtrationthe mixture was filtered through Celite
3. concentrationthe filtrate concentrated under vacuum
4. customThe named product was collected as an oil, which
5. customthen was purified by flash chromatography
6. customto provide a solid product