Dichloromethane → 4-(5-Chloro-2-methoxypyridin-3-yl)-3-trifluoromethoxy-benzylamine

HRID 806234Notes

Reaction equation

HRID 806234 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH2:8][c:9]1[cH:10][c:11]([O:24][C:25]([F:26])([F:27])[F:28])[c:12](-[c:15]2[c:16]([O:22][CH3:23])[n:17][cH:18][c:19]([Cl:21])[cH:20]2)[cH:13][cH:14]1)([CH3:5])([CH3:6])[CH3:29].[Cl:37][CH2:38][Cl:39].[OH:30][C:31]([C:32]([F:33])([F:34])[F:35])=[O:36]>>[NH2:7][CH2:8][c:9]1[cH:10][c:11]([O:24][C:25]([F:26])([F:27])[F:28])[c:12](-[c:15]2[c:16]([O:22][CH3:23])[n:17][cH:18][c:19]([Cl:21])[cH:20]2)[cH:13][cH:14]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67244039[4-(5-Chloro-2-methoxypyridin-3-yl)-3-trifluoromethoxy-benzyl]-carbamic acid-tert-butyl ester

Product 1

HCID 672464734-(5-Chloro-2-methoxypyridin-3-yl)-3-trifluoromethoxy-benzylamine

Sources & evidence

ORD record
ord-2e7dfd35baf746eb8794ca32e5c26fd1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…