HRID806424

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID6422

未命名化合物

结构：COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1

HCID11049999

tert-Butyl 4-({[4-(4-bromo-2-fluoroanilino)-6-methoxyquinazolin-7-yl]oxy}methyl)piperidine-1-carboxylate

C26H30BrFN4O4

PRODUCTS

生成物

结构：COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCNCC1

HCID5329048

N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine

C21H22BrFN4O2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-660c98fad5274dcab0d3c2b61028cf17
来源数据集: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D
来源说明: Test data from https://doi.org/10.1039/C8SC04228D

反应 SMILES

[Br:8][c:9]1[cH:10][c:11]([F:43])[c:12]([NH:13][c:14]2[n:15][cH:16][n:17][c:18]3[cH:19][c:20]([O:26][CH2:27][CH:28]4[CH2:29][CH2:30][N:31]([C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[CH2:32][CH2:33]4)[c:21]([O:24][CH3:25])[cH:22][c:23]23)[cH:41][cH:42]1.[CH2:44]([Cl:45])[Cl:46].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[Br:8][c:9]1[cH:10][c:11]([F:43])[c:12]([NH:13][c:14]2[n:15][cH:16][n:17][c:18]3[cH:19][c:20]([O:26][CH2:27][CH:28]4[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]4)[c:21]([O:24][CH3:25])[cH:22][c:23]23)[cH:41][cH:42]1