2-Propanesulfonyl chloride → 5-((2-(1-(Isopropylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine
Reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[N:12]=[C:11]([CH2:13][O:14][C:15]3[CH:16]=[CH:17][C:18]([N:21]4[CH:25]=[N:24][N:23]=[N:22]4)=[N:19][CH:20]=3)[CH:10]=[N:9]2)[CH2:4][CH2:3]1.[CH:26]([S:29](Cl)(=[O:31])=[O:30])([CH3:28])[CH3:27]>>[CH:26]([S:29]([N:2]1[CH2:3][CH2:4][CH:5]([N:8]2[N:12]=[C:11]([CH2:13][O:14][C:15]3[CH:16]=[CH:17][C:18]([N:21]4[CH:25]=[N:24][N:23]=[N:22]4)=[N:19][CH:20]=3)[CH:10]=[N:9]2)[CH2:6][CH2:7]1)(=[O:31])=[O:30])([CH3:28])[CH3:27]Participants
3
Procedure
The title compound was synthesized using Intermediate 15 and isopropylsulfonyl chloride in a similar manner as described in Example 39. 1H NMR (DMSO-d6): δ 10.08 (1H, s), 8.41 (1H, d), 8.01 (1H, d), 7.95 (1H, s), 7.86 (1H, dd), 5.35 (2H, s), 4.75 (1H, m), 3.69 (2H, m), 3.31 (1H, m), 3.13 (2H, m), 2.17 (2H, m), 1.97 (2H, m), 1.20 (6H, d).
Sources & evidence
- ORD record
- ord-6fd5221400e647cc8a6e8834da8b33ae
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846675B2
Reaction notes
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