HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanesulfonyl chloride → 5-((2-(1-(Isopropylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanesulfonyl chloride | HCID 82408 | — |
| Reactant | 5-((2-(piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine hydrochloride | HCID 68746624 | — |
| Product | 5-((2-(1-(Isopropylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine | HCID 25174425 | — |
Reaction Steps
The title compound was synthesized using Intermediate 15 and isopropylsulfonyl chloride in a similar manner as described in Example 39. 1H NMR (DMSO-d6): δ 10.08 (1H, s), 8.41 (1H, d), 8.01 (1H, d), 7.95 (1H, s), 7.86 (1H, dd), 5.35 (2H, s), 4.75 (1H, m), 3.69 (2H, m), 3.31 (1H, m), 3.13 (2H, m), 2.17 (2H, m), 1.97 (2H, m), 1.20 (6H, d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846675B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-6fd5221400e647cc8a6e8834da8b33ae |
| Source note | uspto-grants-2014_09 |