Sodium borohydride → (1-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol

HRID 80670Notes

Reaction equation

HRID 80670 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[CH:19]=[C:18]([C:20](OCC)=[O:21])[C:17]([C:25]([F:28])([F:27])[F:26])=[N:16]3)[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[BH4-].[Na+]>>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([N:9]2[CH2:10][CH2:11][CH:12]([N:15]3[CH:19]=[C:18]([CH2:20][OH:21])[C:17]([C:25]([F:28])([F:27])[F:26])=[N:16]3)[CH2:13][CH2:14]2)=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 57708415ethyl 1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Product 1

HCID 57708394(1-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol

Procedure

The compound was synthesized using ethyl 1-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate and sodium borohydride in a manner similar to that described in Journal of Medicinal Chemistry, 1996, 29, 341.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-c96b59ad3da349bf8da3d95c198a33ed
Source dataset
uspto-grants-2014_09
Patent number
US08846675B2

Reaction notes

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