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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 80670Generated: October 26, 2026

Sodium borohydride → (1-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol

https://huagongshe.com/reaction/80670

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium borohydrideHCID 4311764—
Reactantethyl 1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylateHCID 57708415—
Product(1-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanolHCID 57708394—

Reaction Steps

The compound was synthesized using ethyl 1-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate and sodium borohydride in a manner similar to that described in Journal of Medicinal Chemistry, 1996, 29, 341.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08846675B2
Source datasetuspto-grants-2014_09
ORD IDord-c96b59ad3da349bf8da3d95c198a33ed
Source noteuspto-grants-2014_09