2-(Methylsulfonyl)-5-(trifluoromethyl)pyrimidine → 2-(4-(4-((2-Fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)-5-(trifluoromethyl)pyrimidine

HRID 80681Notes

Reaction equation

HRID 80681 reaction equation
Cl.[F:2][C:3]1[CH:22]=[C:21]([N:23]2[CH:27]=[N:26][N:25]=[N:24]2)[CH:20]=[CH:19][C:4]=1[O:5][CH2:6][C:7]1[CH:11]=[N:10][N:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH:14]([CH3:18])[CH2:13]2)[N:8]=1.CS([C:32]1[N:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][N:33]=1)(=O)=O>>[F:2][C:3]1[CH:22]=[C:21]([N:23]2[CH:27]=[N:26][N:25]=[N:24]2)[CH:20]=[CH:19][C:4]=1[O:5][CH2:6][C:7]1[CH:11]=[N:10][N:9]([CH:12]2[CH2:17][CH2:16][N:15]([C:32]3[N:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][N:33]=3)[CH:14]([CH3:18])[CH2:13]2)[N:8]=1

Participants

3

Reactant 2

HCID 219837492-(Methylsulfonyl)-5-(trifluoromethyl)pyrimidineHCID 687466114-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride

Product 1

HCID 251750882-(4-(4-((2-Fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)-5-(trifluoromethyl)pyrimidine

Procedure

The title compound was synthesized from 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride and 2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidine in a manner similar to that described in Example 9. The title compound was isolated as a mixture of four stereoisomers.

Sources & evidence

ORD record
ord-d3948998a2b34a329c527b325b08da66
Source dataset
uspto-grants-2014_09
Patent number
US08846675B2

Reaction notes

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