2-(Methylsulfonyl)-5-(trifluoromethyl)pyrimidine → 2-(4-(4-((2-Fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)-5-(trifluoromethyl)pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	2-(Methylsulfonyl)-5-(trifluoromethyl)pyrimidine	HCID 21983749	—
Reactant	4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride	HCID 68746611	—
Product	2-(4-(4-((2-Fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)-5-(trifluoromethyl)pyrimidine	HCID 25175088	—

Reaction Steps

The title compound was synthesized from 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride and 2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidine in a manner similar to that described in Example 9. The title compound was isolated as a mixture of four stereoisomers.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846675B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-d3948998a2b34a329c527b325b08da66
Source note	uspto-grants-2014_09