HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(4-Fluorophenyl)-6-(4-methylpiperazin-1-yl)imidazo[1,2-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 6-Chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine | HCID 11436572 | — |
| Product | 2-(4-Fluorophenyl)-6-(4-methylpiperazin-1-yl)imidazo[1,2-b]pyridazine | HCID 59406960 | — |
Reaction Steps
After heating a suspension of 32 g (97.4 mmol) of 6-chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine (CAS No.: 2069-47-8) in 200 ml of 1-methylpiperazine at 160° C. for 16 hours, the mixture is poured into 1.5 L of water. The yellowish precipitate formed is separated out by filtration and rinsed with cold isopropanol and then with diisopropyl ether. 30 g of a beige-colored powder are thus isolated after drying under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846676B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-d43d48bd56824c8d871128c4b090b0e9 |
| Source note | uspto-grants-2014_09 |