Water → 2-(4-Fluorophenyl)-6-(4-methylpiperazin-1-yl)imidazo[1,2-b]pyridazine

HRID 80706Notes

Reaction equation

HRID 80706 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[N:7]=1.O.[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:10]=[C:5]3[CH:4]=[CH:3][C:2]([N:23]4[CH2:24][CH2:25][N:20]([CH3:19])[CH2:21][CH2:22]4)=[N:7][N:6]3[CH:8]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 962WaterHCID 531671-MethylpiperazineHCID 114365726-Chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine

Product 1

HCID 594069602-(4-Fluorophenyl)-6-(4-methylpiperazin-1-yl)imidazo[1,2-b]pyridazine

Procedure

After heating a suspension of 32 g (97.4 mmol) of 6-chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine (CAS No.: 2069-47-8) in 200 ml of 1-methylpiperazine at 160° C. for 16 hours, the mixture is poured into 1.5 L of water. The yellowish precipitate formed is separated out by filtration and rinsed with cold isopropanol and then with diisopropyl ether. 30 g of a beige-colored powder are thus isolated after drying under vacuum.

Workup

  1. temperatureAfter heating
  2. customThe yellowish precipitate formed
  3. customis separated out by filtration
  4. washrinsed with cold isopropanol

Sources & evidence

ORD record
ord-d43d48bd56824c8d871128c4b090b0e9
Source dataset
uspto-grants-2014_09
Patent number
US08846676B2

Reaction notes

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